An altered extracellular matrix-integrin interface contributes to Huntington's disease-associated CNS dysfunction in glial and vascular cells.
Hernandez SJ, Lim RG, Onur T, Dane MA, Smith R, Wang K, Jean GE, Reyes-Ortiz A, Devlin K, Miramontes R, Wu J, Casale M, Kilburn D, Heiser LM, Korkola JE, Van Vactor D, Botas J, Thompson-Peer KL, Thompson LM.
Hernandez SJ, et al.
Hum Mol Genet. 2023 Apr 20;32(9):1483-1496. doi: 10.1093/hmg/ddac303.
Hum Mol Genet. 2023.
PMID: 36547263
Free PMC article.
Defining the contribution of these cells to disease can inform cell-type-specific effects and uncover new disease-modifying therapeutic targets. These cells express integrin (ITG) adhesion receptors that anchor the cells to the extracellular matrix (ECM) to maintain the in …
Defining the contribution of these cells to disease can inform cell-type-specific effects and uncover new disease-modifying therapeutic targ …